2-TOIFA DIABET VA YURAK ISHEMIK KASALLIKLARI BILAN OG'RIGAN BEMORLARDA NOS-3 GENINING GLU298ASP POLIMORFIZMINING ENDOTELIAL FUNKTSIYA PARAMETRLARIGA TA'SIRI
Abstract
2-toifa qandli diabet (T2DM) va yurak ishemik kasalliklari (YuIK) kombinatsiyasi ko'pincha endotelial disfunktsiya va gemodinamikaning yomonlashishi bilan birga keladi. Ushbu o'zgarishlarning shakllanishida genetik omillarning, xususan, NOS-3 genining Glu298Asp polimorfizmining rolini o'rganish qon tomir asoratlarni rivojlanish mexanizmlarini tushunish va oldini olish va davolashning yangi maqsadlarini izlash yo'lidagi muhim qadamdir.
References
1. Piepoli M. F., Hoes A. W., Agewall S., Albus C., Brotons C. et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice. European Heart Journal. 2016; 37: 2315–2381.
2.Орлова Н. В. Генетическая обусловленность воспаления при атеросклероти-ческом поражении сосудов сердца. Сердечная недостаточность. 2008; 9 (4): 180–3.
3. Чукаева И. И., Орлова Н. В., Алешкин В. А., Пухальский А. Л. Воспалитель-ные реакции у больных ишемической болезньюсердца с сопутствующими ожирением и сахарным диабетом 2 типа. Клиниче-ская медицина. 2008; 1: 27–30.
4. Bautista L. E., Veram L. M., Arenas I. A., Gamarra G. Independent association between inflammatory markers (Creactive protein, interleukin6, and TNFa) and essential hypertension. J. Hum. Hypertension 2005; 19: 149–154.
5.Shoulders C. C., Jones E. L., Naoumova R. P. Genetics of familial combined hyperlipidemia and risk of coronary heart disease. Human. Molecular Genetics. 2004; 13: 149–160.
6. Hribal M. L., Federici M., Porzio O. The GlyArg972 amino acid polimorphism in IRS1 affects glucose metabolism in skeletal muscle cells. J. Clin.Endocrinol. Metab. 2000; 85: 2004–2013.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Abdullaeva Ch.A., Jurayev M.I., Raxmonov R.R. (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
All Rights Reserved.
