USE OF DULOXETINE IN CHRONIC PAIN SYNDROME
Keywords:
“duloxetine,” “antidepressants,” “serotonin,” and “chronic pain syndrome.”Abstract
Chronic pain represents a significant challenge in clinical medicine, leading to substantial physical, emotional, and social burdens. Duloxetine, a serotonin-norepinephrine reuptake inhibitor (SNRI), has emerged as an effective pharmacological option for managing conditions such as diabetic neuropathy, fibromyalgia, and osteoarthritis. This study aims to explore the pharmacological mechanisms, efficacy, and safety of duloxetine in chronic pain management.
References
1. Preskorn, S. H. (2004). "Duloxetine: a balanced and selective serotonin and norepinephrine reuptake inhibitor." Journal of Clinical Psychiatry, 65(3), 19-28.
2. Bymaster, F. P., Dreshfield-Ahmad, L. J., Threlkeld, P. G., et al. (2001). "Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters." European Journal of Pharmacology, 432(2-3), 193-197.
3. Wernicke, J. F., Pritchett, Y. L., D'Souza, D. N., et al. (2007). "A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain." Neurology, 67(8), 1411-1420.
4. Detke, M. J., Lu, Y., Goldstein, D. J., et al. (2002). "Duloxetine in the acute treatment of major depressive disorder: A double-blind placebo-controlled trial." Journal of Clinical Psychiatry, 63(3), 225-231.
5. Llorca, P. M., Fernandez, J. L., & Carrière, P. (2005). "The safety and tolerability of duloxetine in the treatment of major depressive disorder." Journal of Clinical Psychiatry, 66(Suppl 10), 30-36.
6. Fava, M., Evins, A. E., Dorer, D. J., et al. (2003). "The effect of duloxetine on suicidality in adult patients with depression or generalized anxiety disorder." Journal of Clinical Psychiatry, 64(12), 1300-1310.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Sattarova Dilrabo (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
All Rights Reserved.
